1). Conditional survival prediction model in DLBCL
2). Meta-analysis in CAR-T studies
3). Statistical Programming with SAS
4). Gene signatures in stem cell-like B cell
5). Early life respiratory viral infection and immune development
6). SARS-CoV-2 infection in children and asthma
With a diverse background spanning biomedical and biostatistical research, my work lies in exploring the application of biostatistics related to both laboratory and clinical research. I collaborate with experts in Hematology-Oncology, Prostate Cancer, Lung Cancer, Breast Cancer, Pathology, Pharmacology, Pediatrics, and Alzheimer’s Disease. The expertise of my team encompasses experimental design, biomarker discovery from high-dimensional genomic data, correlative clinical studies, research involving laboratory animals, and early clinical trials.
Currently, we are deeply engaged in multiple NIH grants, where I serve as a co-investigator and biostatistician. Additionally, I hold the role of co-director for the Bioinformatics and Biostatistics Core within the Specialized Center of Research (SCOR) grant funded by the Leukemia & Lymphoma Society (LLS). I also co-direct the Biostatistics core for an NIH P01 center grant focused on Mantle Cell Lymphoma. At WCM, I contribute to crucial decision-making processes as a member of multiple Disease Management Teams (DMT) of the Cancer Center, the Protocol Review and Monitoring Committee (PRMC) and the Data Safety Monitoring Committee (DSMC).
My commitment extends to education, where I actively participate in teaching and serve as the course director for two courses in the Biostatistics and Data Science graduate program.
Biography
Dr. Chen earned his PhD in cancer molecular biology from Xiamen University, China, and later pursued an MPH in biostatistics from the University of South Florida, Tampa, Florida. Prior to joining Weill Cornell Medicine in 2011 as a Biostatistician, he conducted research on molecular signal transduction in cancer at the National University of Singapore (NUS, Singapore), H Lee Moffitt Cancer Center in Florida, and Karmanos Cancer Institute in Detroit. He joined the faculty of Population Health Sciences in 2016.
Distinctions:
2018 SAS faculty award
2018- Editor board of Leukemia & Lymphoma
2020- Associate editor of Frontiers in Oncology
Selected Publications:
Yamshon S, et al. Efficacy and Toxicity of CD19 Chimeric Antigen Receptor T Cell Therapy for Lymphoma in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis. Transplant Cell Ther. 2023
Mlynarczyk C, et al. BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science. 2023
Erazo T, et al. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Nat Commun. 2022
Han Y, et al. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022
Gibson GE, et al. Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial. J Alzheimers Dis. 2020
