My lab investigates the fundamental mechanisms of cell death and cell survival, as well as their roles in normal biology and disease; we aim to translate our basic research finding into novel therapies.
The research of my laboratory focuses on two directions highly relevant to cancer biology, (1) the molecular basis of programmed cell death processes (including apoptosis and ferroptosis), and their roles in human disease; and (2) the molecular basis of autophagy and its role in cancer. We also study various cancer signaling and cellular metabolic events, especially those involved in cell death/survival determination. We aim to translate our basic research finding into potential therapeutic approaches. To achieve these goals, the laboratory utilizes a combination of approaches including biochemistry, chemical biology, proteomics, molecular cell biology, high-throughput screening, 3-dimensional microfluidic cell array, and mouse modeling.
Biography
Xuejun Jiang earned his bachelor’s and master’s degrees in Biochemistry at Fudan University, China in 1990 and 1993 respectively. In 1999, Jiang completed his PhD degree at Pharmacology Department, University of Texas Southwestern Medical Center (UTSW), under the mentorship of Dr. Paul Sternweis. He then joined the Lab of Dr. Xiaodong Wang at UTSW as a postdoctoral fellow to study apoptosis. In 2003, he joined MSKCC to establish his own independent lab. Xuejun is now a Member of MSKCC and a Professor at both Gerstner Sloan Kettering Graduate School and Cornell University Weill Medical College.
Distinctions:
2007 Louis and Allston Boyer Young Investigator Award
2007-2010 American Cancer Society Scholar
2006-2010 Catherine and Frederick Adler Chair for junior faculty
