Jochen Buck

I received my MD and PhD degree from the Eberhard Karl University of Tübingen followed by post doctoral training at Memorial Sloan-Kettering Cancer Center. In 1992 I started as an Assistant Professor in the Department of Pharmacology at Weill Cornell Medicine and since 2002 Dr. Lonny Levin and I co-lead our shared laboratory.

Distinctions: 

• Pew Scholar in Biomedical Sciences
• Senior Scholar of the Ellison Medical Foundation

Selected Publications: 

• Balbach, M., Rossetti, T., Ferreira, J. et al. On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat Commun 14, 637 (2023).
• Hess, K. C., Jones, B. H., Marquez, B., Chen, Y., Ord, T. S., Kamenetsky, M., Miyamoto, C., Zippin, J. H., Kopf, G. S., Suarez, S. S., Levin, L. R., Williams, C. J., Buck, J., & Moss, S. B. (2005). The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Developmental cell, 9(2), 249–259.
• Kleinboelting, S., Diaz, A., Moniot, S., van den Heuvel, J., Weyand, M., Levin, L. R., Buck, J., & Steegborn, C. (2014). Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proceedings of the National Academy of Sciences of the United States of America, 111(10), 3727–3732.
• Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000). Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science (New York, N.Y.), 289(5479), 625–628.
• Buck, J., Sinclair, M. L., Schapal, L., Cann, M. J., & Levin, L. R. (1999). Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proceedings of the National Academy of Sciences of the United States of America, 96(1), 79–84.