Our group applies digital tools to characterize cancer therapy-related side effects and to deliver exercise interventions to mitigate treatment toxicities.
Ongoing NIH-funded trials (R01CA272733, R37CA248665, U01CA271287) test whether adjusting exercise training dose and/or duration can reduce fitness non-response rates or improve chemotherapy tolerability. This work challenges the prevailing “one-size-fits-all” approach and advances personalized exercise prescriptions using machine learning to identify subgroup-specific predictors of fitness response. To implement trials testing higher exercise volumes while reducing patient burden, our group developed Tele-Ex, a telemedicine platform for delivering rigorous, home-based exercise interventions.
Biography
Jessica Scott received her PhD from the University of British Columbia, where she studied the effects of prolonged endurance exercise on cardiac function in athletes and heart transplantation recipients. She completed a postdoctoral fellowship at NASA Johnson Space Center and spent five years as a Senior Scientist in the Exercise Physiology and Countermeasures Laboratory before joining Memorial Sloan Kettering Cancer Center.
Distinctions:
Co-Chair, National Academy of Sciences Committee on Biological and Physical Sciences in Space
NASA Group Achievement Award
NASA Innovation Achievement Award
NASA Human Research Program Peer Award
Selected Publications:
Scott, J. M., Lee, J., Herndon, J. E., Michalski, M. G., Lee, C. P., O'Brien, K. A., Sasso, J. P., Yu, A. F., Rowed, K. A., Bromberg, J. F., Traina, T. A., Gucalp, A., Sanford, R. A., Gajria, D., Modi, S., Comen, E. A., D'Andrea, G., Blinder, V. S., Eves, N. D., Peppercorn, J. M., … Jones, L. W. (2023). Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial.European heart journal, 44(46), 4878–4889.
Scott, J. M., Li, N., Liu, Q., Yasui, Y., Leisenring, W., Nathan, P. C., Gibson, T., Armenian, S. H., Nilsen, T. S., Oeffinger, K. C., Ness, K. K., Adams, S. C., Robison, L. L., Armstrong, G. T., & Jones, L. W. (2018). Association of Exercise With Mortality in Adult Survivors of Childhood Cancer.JAMA oncology, 4(10), 1352–1358.
