Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host disease with a high fundamental and translational impact. His work identified specialized stromal niches that represent the critical sources of Notch ligands in secondary lymphoid organs, sparking a new interest in the biology of lymphoid tissue fibroblastic reticular cells in immune and hematologic disorders.
Biography
Dr. Maillard is a hematologist and physician-scientist who earned MD and PhD degrees in Switzerland, followed by clinical and post-doctoral training in Switzerland and at the University of Pennsylvania. He started his independent career at the University of Michigan where he stayed for 10 years before joining Penn in 2018 the Vice-Chief for Research in the Division of Hematology/Oncology. In 2024, Dr. Maillard was recruited to MSK where he leads the Division of Hematologic Malignancies and serves as the Laurence Joseph Dineen Chair in Leukemia Research as well as Professor of Medicine at WCMC.
Distinctions:
Member, Association of American Physicians (2024)
Interurban Clinical Club (2019)
DuPont Guerry, IV, MD Award for Outstanding Mentorship, University of Pennsylvania Perelman School of Medicine (2019)
League of Research Excellence, University of Michigan Medical School (2014)
Member, American Society of Clinical Investigation (2013)
Tkachev V*, Vanderbeck A*, Perkey E*, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Burbach B, Shimizu Y, Panoskaltsis-Mortari, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS**, Maillard I**. Notch signaling drives intestinal graft-versus-host disease in mice and non-human primates. Science Translational Medicine 15(702):eadd175, 2023. PMID: 37379368
Allman A*, Gaudette BT*, Kelly S*, Alouche N*, Carrington L, Perkey E, Brandstadter JD, Outen R, Vanderbeck A, Lederer K, Zhou Y, Faryabi RB, Robertson TF, Burkhardt JK, Tikhonova A, Aifantis I, Scarpellino L, Koch U, Radtke F, Lütge M, De Martin A, Ludewig B, Tveriakhina L, Gossler A, Mosteiro L, Siebel CW, Gómez Atria D, Luther SA, Allman D**, Maillard I**. Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity 2025. Jan 14;58(1):143-161.e8. doi: 10.1016/j.immuni.2024.12.003. PMCID: PMC11735314
